Funding and salary support

This work was supported by funding from the Canadian Institutes of Health Research (CIHR) to A-C.G. and T.P. (MOP 123322). A.-C.G. holds the Canada Research Chair in Functional Proteomics and the Lea Reichmann Chair in Cancer Proteomics. J.-P.L was supported by a post-doctoral fellowship from CIHR.

Other acknowledgments

We want to thank Guo Ci Teo and Hyungwon Choi (National University of Singapore) for providing access to the optimized SAINTexpress algorithm used in this study. We also wish to thank Wade Dunham for manuscript editing and the Gingras and Pawson labs for helpful discussion.