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This work was supported by operating grants from the Natural Sciences and Engineering Research Council of Canada (RGPIN-2017-05819 to D.R.H.; RGPIN-2016-04808 to J.F.C) and the Canadian Institutes of Health Research (FDN144301 to A.C.G.). H.B., N.S. and V.T. were recipients of Fonds de Recherche Santé Québec Doctoral studentships and I.E. was supported by an IRCM Foundation-TD scholarship. J.-F.C. holds the Transat Chair in Breast Cancer Research.