Grants

This work was supported by a Cancer Research Society (CRS) grant to A.-C.G., a Terry Fox Research Institute team grant (to F.S. and A.-C.G.), a Canadian Cancer Society Research Institute Impact grant to F.S., as well as by Canadian Institutes of Health Research Foundation Grants (FDN 143277 to F.S.; FDN 143301 to A.-C.G.).

A.-C.G. and F.S are the Canada Research Chairs (Tier 1) in Functional Proteomics and Structural Biology of Cell Signaling, respectively.
S.X. is supported by Natural Sciences and Engineering Research Council of Canada Doctoral Awards.
S.G. was supported by postdoctoral fellowships from the Human Frontier Science Program (HFSP) and the European Molecular Biology Organization (EMBO).
For paper 1: P.F. and S.P. are supported by a Wellcome Career Development Fellowship (095751/Z/11/Z).
For paper 2: M.J.K. was supported by the Canadian Institutes of Health Research through a Banting and Best Canada Graduate Scholarship.

Proteomics work was performed at the Network Biology Collaborative Centre at the Lunenfeld-Tanenbaum Research Institute, a facility supported by Canada Foundation for Innovation funding, by the Ontario Research Fund and by Genome Canada and the Ontario Genomics (OGI-088; to A.-C.G.).
Diffraction work conducted at the Northeastern Collaborative Access Team beamlines was funded by the National Institute of General Medical Sciences from the National Institutes of Health (P41 GM103403) and by an NIH-ORIP HEI grant (S10 RR029205).