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Work in the Gingras lab was supported by a Canadian Institutes of Health Research (CIHR) Foundation Grant (FDN 143301). Proteomics work was performed at the Network Biology Collaborative Centre at the Lunenfeld-Tanenbaum Research Institute, a facility supported by Canada Foundation for Innovation, by the Ontario Research Fund and by Genome Canada and the Ontario Genomics (OGI-088). Work in the Filippakopoulos lab was supported by Ludwig Institute Cancer Research and the SGC, a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada, Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck & Co., Novartis Pharma AG, Ontario Ministry of Economic Development and Innovation, Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome Trust (092809/Z/10/Z). Genomics work was supported by Natural Sciences and Engineering Research Council of Canada (NSERC) grant 436194-2013 to M.W. N.B. was partially supported by US National Institutes of Health (NIH) grants 5P41GM103484.

P.F. and S.P. are supported by a Wellcome Career Development Fellowship (095751/Z/11/Z). A.-C.G., L.P. and M.D.W. are Canada Research Chairs in Functional Proteomics, Centrosome Biogenesis and Function and Comparative Genomics, respectively. J.P.L. was funded through fellowships from the Natural Sciences and Engineering Research Council of Canada (NSERC), CIHR, TD Bank (Health Research Fellowship) and the Cancer Research Society (Scholarship for the Next Generation of Scientists). T.F. is supported by a Uehara Memorial Foundation Fellowship (201330102). M.W is supported by an Early Researcher Award from the Ontario Ministry of Research, Innovation and Science. L.U. is supported by the Estonian Research Council (PUTJD145). H.H was supported by a University of Toronto Open Fellowship Award. N.B. was supported as an Alfred P. Sloan Fellow. N.S. was supported by fellowships from CIHR and TD Bank (Health Research Fellowship).